Associate ProfessorDonata Pluskota-Karwatka

Associate Professor

    An employee of the Department of Chemistry of Natural Products. Till the end of 2019, an employee of the Department of Synthesis and Structure of Organic Compounds. 1989 scientific internship at the Institute of Bioorganic Chemistry of the Polish Academy of Sciences in Poznań. 1997-1999 postdoctoral fellowship at the Department of Organic Chemistry, Åbo Akademi University (Turku, Finland, prof. Leif Kronberg). 2001, 2002 and 2005 several-month scientific internships at the Department of Organic Chemistry, Åbo Akademi University. 1998-1999 scholarship from the Jenny and Antii Wihuri Foundation.  From January 2014, prof. UAM

  • Head of Interdisciplinary and International PhD Studies in the field of biology, chemistry and nanostructures in 2017-2020.
  • Member of the Qualification Team (discipline: chemical sciences) for the selection of candidates for the Adam Mickiewicz University Doctoral School in 2019 and 2020.
  • Member of the Expert Committee in projects: HighChem, ChemInter and INNChem.
  • In the years: 2007, 2018 and 2019, Awards of the Rector of Adam Mickiewicz University in Poznań for achievements in scientific, didactic and organizational work.
  • Organic and bioorganic chemistry.
  • Structural modifications of DNA bases and amino acids: studies of interactions between biomolecules and endogenously formed carbonyl compounds, studies of mechanisms of DNA adducts inducing and cross-links formation.
  • Synthesis and structural studies of fluorinated phosphonate analogues of amino acids and other biologically active compounds.
  1. F. Le Curieux, D. Pluskota, T. Munter, R. Sjöholm and L. Kronberg
    Formation of a fluorescent adduct in the reaction of 2'-deoxyadenosine with a malonaldehyde-acetaldehyde condensation product.
    Chem. Res. Toxicol, 1998, 11, 989-994.
  2. F. Le Curieux, D. Pluskota, T. Munter, R. Sjöholm and L. Kronberg
    Identification of fluorescent 2'-deoxyadenosine adducts formed in reactions of conjugates of malonaldehyde and acetaldehyde, and of malonaldehyde and formaldehyde.
    Chem. Res. Toxicol, 2000, 13, 1228-1234.
  3. D. Pluskota-Karwatka, F. Le Curieux, T. Munter, R. Sjöholm and L. Kronberg
    Formation of conjugate adducts in the reaction of malonaldehyde-acetaldehyde and malonaldehyde-formaldehyde with guanosine.
    Chem. Res. Toxicol., 2005, 18, 300-307.
  4. D. Pluskota-Karwatka, A. J. Pawłowicz and L. Kronberg
    Formation of malonaldehyde-acetaldehyde adducts in calf thymus DNA.
    Chem. Res. Toxicol., 2006, 19, 921-926.
  5. D. Pluskota-Karwatka, A. J. Pawłowicz, M. Tomas and L. Kronberg
    Formation of adducts in the reaction of glyoxal with 2¢-deoxyguanosine and with calf thymus DNA.
    Bioorg. Chem., 2008, 36, 57-64.
  6. D. Pluskota-Karwatka, D. Matysiak, M. Makarewicz, L. Kronberg
    Reactivity of the malonaldehyde-glyoxal and malonaldehyde-methylglyoxal adducts of adenine nucleosides towards amino acid cross-link formation.
    Eur. J. Org. Chem., 2012, 4797-4804.
  7. D. Pluskota-Karwatka, M. Muńko, M. Hoffmann, M. Kuta, L. Kronberg
    Studies on the reactions between the DNA bases and a model α,β-unsaturated oxoaldehyde.
    New Journal of Chemistry, 2015, 39, 9171-9180.
  8. K. Salus, M. Hoffmann, T. Siodła, B. Wyrzykiewicz, D. Pluskota-Karwatka
    Synthesis, structural studies and stability of model cysteine containing DNA–protein cross-links.
    New Journal of Chemistry, 2017, 41, 2409–2424.
  9. D. Jarmużek, T. Pedzinski, M. Hoffmann, T. Siodła, K. Salus and D. Pluskota-Karwatka
    Experimental and theoretical studies on fluvastatin primary photoproduct formation.
    Physical Chemistry Chemical Physics, 2017, 19, 21946-21954.
  10. A. Pawłowska, J.-N. Volle, D. Virieux, J.-L. Pirat, A. Janiak, M. Nowicki, M. Hoffmann, D. Pluskota-Karwatka
    Perfluorophenyl phosphonate analogues of aromatic amino acids: synthesis, X-ray and DFT studies.
    Tetrahedron, 2018, 74, 975-986.
  11. J. Kwiczak-Yiğitbaşı, J-L. Pirat, D. Virieux, J-N. Volle, A. Janiak, M. Hoffmann, D. Pluskota-Karwatka
    Fluorinated phosphonate analogues of phenylalanine: synthesis, X-ray and DFT studies.
    Arabian J. Chem    ., 2020, 13, 2384-2399.
  12. J. Kwiczak-Yiğitbaşı, J-L. Pirat, D. Virieux, J-N. Volle, A. Janiak, M. Hoffmann, Jakub Mrzygłód, Dariusz Wawrzyniak, Jan Barciszewski, D. Pluskota-Karwatka Synthesis, structural studies and biological properties of some phosphonoperfluorophenylalanine derivatives formed by SNAr reactions.
    RSC Adv., 2019, 9, 24117-24133.
  13. D. Jarmużek, T. Pedzinski, M. Hoffmann, T. Siodła, D. Pluskota-Karwatka Phototransformations of pitavastatin - The inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
    J. Photochem. Photobiol. A: Chem., 2020, 389, 112243.